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Ethyl 1-(6-chloronaphth-2-ylsulphonyl)piperazine-3-carboxylate → 4-(6-Chloronaphth-2-ylsulphonyl)-2-ethoxycarbonyl-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 1-(6-chloronaphth-2-ylsulphonyl)piperazine-3-carboxylate | HCID 10970999 | — |
| 反応物 | 1-(4-Pyridinyl)-4-piperidinecarbonyl chloride | HCID 11183700 | — |
| 生成物 | 4-(6-Chloronaphth-2-ylsulphonyl)-2-ethoxycarbonyl-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine | HCID 22721818 | 37% |
反応手順
Using an analogous procedure to that described in Example 1, 1-(4-pyridyl)piperidine-4-carbonyl chloride was reacted with ethyl 1-(6-chloronaphth-2-ylsulphonyl)piperazine-3-carboxylate to give 4-(6-chloronaphth-2-ylsulphonyl)-2-ethoxycarbonyl-1-[1-(4-pyridyl)-piperidin-4-ylcarbonyl]piperazine in 37% yield;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06730672B2 |
| 出典データセット | uspto-grants-2004_05 |
| ORD ID | ord-d639e0372d314a96847a5fba7c1bad80 |
| 出典メモ | uspto-grants-2004_05 |