Boron tribromide → 2-Fluoro-6-iodophenol

To a solution of 2-fluoro-6-iodoanisole (Justus Liebigs, Ann. Chem., 746:134, 1971; 4.31 g, 17.1 mmol) in dichloromethane (35 ml) is added a 1M solution of boron tribromide in dichloromethane (18.2 ml). The mixture is kept under argon and stirred for 4 hours at room temperature. The mixture is poured into a saturated aqueous sodium bicarbonate solution and the aqueous layer is extracted with ethyl acetate. The combined organic layers are dried over sodium sulfate and concentrated under reduced pressure to give 2-fluoro-6-iodophenol (4.2 g).

1. extractionthe aqueous layer is extracted with ethyl acetate
2. dry with materialThe combined organic layers are dried over sodium sulfate
3. concentrationconcentrated under reduced pressure

ORDレコード

ord-f5aad8bdf73c43179351086bcd41f088

出典データセット

uspto-grants-2004_05

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06730792B2