Boron tribromide → 2-(1H-pyrazol-4-yl)phenol

HRID 1581808ノート

反応式

HRID 1581808 の反応式
C[O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[N:11][NH:12][CH:13]=1.B(Br)(Br)Br>ClCCl>[NH:11]1[CH:10]=[C:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[OH:2])[CH:13]=[N:12]1

参加物

4

反応物 2

HCID 25134Boron tribromideHCID 227234704-(2-Methoxyphenyl)-1H-pyrazole

生成物 1

HCID 227234562-(1H-pyrazol-4-yl)phenol収率 98%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of 4-(2-methoxyphenyl)pyrazole (300 mg, 1.72 mmol) in dichloromethane (13 ml) is added a 1M solution of boron tribromide (3.8 ml) in dichloromethane. The mixture is stirred at room temperature over night then concentrated under reduced pressure. The residue is chromatographed (silica gel, dichloromethane/ethanol 9:1) to give 270 mg of 2-(pyrazol-4-yl)phenol (98%).

後処理

  1. concentrationthen concentrated under reduced pressure
  2. customThe residue is chromatographed (silica gel, dichloromethane/ethanol 9:1)

出典と根拠

ORDレコード
ord-dfe1e48f283d449cb79bdc8f3c9fde14
出典データセット
uspto-grants-2004_05
特許番号
US06730792B2

反応ノート

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