BISOPROLOL FUMARATE → Bisoprolol

HRID 1581900ノート

反応式

HRID 1581900 の反応式
[CH3:1][CH:2]([NH:4][CH2:5][CH:6]([OH:23])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][CH2:17][CH2:18][O:19][CH:20]([CH3:22])[CH3:21])=[CH:13][CH:14]=1)[CH3:3].C(/C(O)=O)=C\C(O)=O>O>[CH3:3][CH:2]([NH:4][CH2:5][CH:6]([OH:23])[CH2:7][O:8][C:9]1[CH:10]=[CH:11][C:12]([CH2:15][O:16][CH2:17][CH2:18][O:19][CH:20]([CH3:22])[CH3:21])=[CH:13][CH:14]=1)[CH3:1]

参加物

3

反応物 1

HCID 6917733BISOPROLOL FUMARATE

生成物 1

HCID 2405Bisoprolol

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of bisoprolol was prepared as follows. To 529.2 g of purified water were added 180 g of bisoprolol fumarate 2:1. The mixture was stirred for 10 minutes to dissolve the drug. 10.8 g of talc USP (Whitaker, Clark and Daniels Inc., South Plainfield, N.J., USA) were added to the solution and the mixture was stirred for 20 minutes.

後処理

  1. dissolutionto dissolve the drug
  2. stirringthe mixture was stirred for 20 minutes

出典と根拠

ORDレコード
ord-481f489f89154a1d87d9b2d300813349
出典データセット
uspto-grants-2004_05
特許番号
US06733789B1

反応ノート

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