2-Aminoindane → 4-(2-Indanylamino)-7-methylthieno[3,2-d]pyrimidine

HRID 1581964

反応式

HRID 1581964 の反応式
Cl[C:2]1[C:3]2[S:10][CH:9]=[C:8]([CH3:11])[C:4]=2[N:5]=[CH:6][N:7]=1.[NH2:12][CH:13]1[CH2:21][C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:14]1>C(O)C>[CH2:14]1[C:15]2[C:20](=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:21][CH:13]1[NH:12][C:2]1[C:3]2[S:10][CH:9]=[C:8]([CH3:11])[C:4]=2[N:5]=[CH:6][N:7]=1

参加物

4

反応物 2

HCID 763102-AminoindaneHCID 27775864-Chloro-7-methylthieno(3,2-d)pyrimidine

生成物 1

HCID 120940604-(2-Indanylamino)-7-methylthieno[3,2-d]pyrimidine収率 75%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4-chloro-7-methylthieno[3,2-d]pyrimidine (74 mg, 0.40 mmol) and 2-aminoindan (270 mg, 2.0 mmol) in dry ethanol (3 ml) were heated to reflux under an argon atmosphere for 1 hour. The solvent was distilled off under reduced pressure and the residue obtained was purified by silica gel chromatography (hexane:ethyl acetate=1:1) to obtain the title compound (83 mg, 0.30 mmol) having the following physical properties:

後処理

  1. temperatureto reflux under an argon atmosphere for 1 hour
  2. distillationThe solvent was distilled off under reduced pressure
  3. customthe residue obtained
  4. customwas purified by silica gel chromatography (hexane:ethyl acetate=1:1)

出典と根拠

ORDレコード
ord-08248aebde1249619cb8415bd0c33f2c
出典データセット
uspto-grants-2004_05
特許番号
US06734180B1

関連ノート

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