1,4-Dioxane hydrochloride → 2-amino-5-((E)-2-(4-methylphenyl)ethenyl]indan hydrochloride

HRID 1581990ノート

反応式

HRID 1581990 の反応式
C(OC([NH:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14](/[CH:18]=[CH:19]/[C:20]3[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=3)[CH:15]=2)[CH2:10]1)=O)(C)(C)C.[ClH:27].O1CCOCC1>C(O)(=O)C>[ClH:27].[NH2:8][CH:9]1[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14](/[CH:18]=[CH:19]/[C:20]3[CH:21]=[CH:22][C:23]([CH3:26])=[CH:24][CH:25]=3)[CH:15]=2)[CH2:10]1

参加物

4

反応物 2

HCID 204431481,4-Dioxane hydrochlorideHCID 227196342-(tert-Butoxycarbonylamino)-5-[(E)-2-(4-methylphenyl)ethenyl]indan

生成物 1

HCID 227195902-amino-5-((E)-2-(4-methylphenyl)ethenyl]indan hydrochloride

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

Using 2-(tert-butoxycarbonylamino)-5-[(E)-2-(4-methylphenyl)ethenyl]indan (20 mg, 0.060 mmol) synthesized in Preparation Example 2, 4N hydrochloric acid-dioxane (2.0 ml) and acetic acid (6.0 ml), a similar procedure to Example 24 was carried out to obtain 2-amino-5-[(E)-2-(4-methylphenyl)ethenyl]indan hydrochloride (16 mg, 0.06 mmol) having the following physical properties:

出典と根拠

ORDレコード
ord-d2497058e0664f74a8173ce962937995
出典データセット
uspto-grants-2004_05
特許番号
US06734180B1

反応ノート

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