Tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate → 8-Boc-3,8-diaza-bicyclo(3.2.1)octane

HRID 1582395

反応式

HRID 1582395 の反応式
C([N:8]1[CH2:14][CH:13]2[N:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:10]([CH2:11][CH2:12]2)[CH2:9]1)C1C=CC=CC=1>CO>[CH:10]12[N:15]([C:16]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:13]([CH2:12][CH2:11]1)[CH2:14][NH:8][CH2:9]2

参加物

3

反応物 1

HCID 15740907Tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate

生成物 1

HCID 157409088-Boc-3,8-diaza-bicyclo(3.2.1)octane収率 94%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate, Pd(OH)2-C (1.1 g) in MeOH (22 mL) was stirred under hydrogen atmosphere (4 atm) for 10 h at room temperature. The mixture was filtered through celite and the filtrate was concentrated in vacuo to give a product (1.45 g, 94%) as a white solid. This product was used for next step without purification.

後処理

  1. filtrationThe mixture was filtered through celite
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-17272f175eda4dd6903bd2c6793b68a5
出典データセット
uspto-grants-2004_05
特許番号
US06734306B2

関連ノート

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