Hydrochloric Acid → Ethyl 2,4-dimethoxy-benzimidate hydrochloride

HRID 1582461

反応式

HRID 1582461 の反応式
[ClH:1].[CH3:2][O:3][C:4]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7].[CH2:14]([OH:16])[CH3:15]>>[ClH:1].[CH3:2][O:3][C:4]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:5]=1[C:6](=[NH:7])[O:16][CH2:14][CH3:15]

参加物

4

反応物 3

HCID 313Hydrochloric Acid2 回HCID 702EthanolHCID 777502,4-Dimethoxybenzonitrile

生成物 1

HCID 22721088Ethyl 2,4-dimethoxy-benzimidate hydrochloride収率 57%

実験手順

Hydrogen chloride gas was passed through a solution of 2,4-dimethoxy-benzonitrile (5.20 g, 32 mmol) in anhydrous ethanol (200 mL) at 0° C. After 7 h, hydrogen chloride gas was stopped and the reaction mixture was stirred at room temperature overnight. The solvent was removed and the residue was triturated in diethyl ether to afford ethyl 2,4-dimethoxy-benzimidate hydrochloride (4.5 g, 57%). It was used without further purification.

後処理

  1. customThe solvent was removed
  2. customthe residue was triturated in diethyl ether

出典と根拠

ORDレコード
ord-8df2d3d2fdad44ba9f89268a3002e98f
出典データセット
uspto-grants-2004_05
特許番号
US06734302B2

関連ノート

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