2-Bromophenol → 2-(2-bromophenoxy)ethanol
反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].Br[CH2:10][CH2:11][OH:12].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH2:10][CH2:11][OH:12]参加物
5
反応条件
- 温度
- 100 °C
実験手順
In a nitrogen atmosphere, 2-bromophenol 5.0 g, 2-bromoethanol 5.42 g, and potassium carbonate 12.0 g were added to N,N-dimethylformamide 30 ml, and the mixture was stirred at 100° C. After about 2.5 hours, the reaction mixture was cooled to room temperature and partitioned by adding water and diethyl ether. The organic layer was washed with water and then with brine, dried over magnesium sulfate anhydride and evaporated. The residue was purified by silica gel column chromatography (hexane/ethyl acetate system), whereby the title compound 5.09 g, 81% was obtained as a colorless oil.
後処理
- temperaturethe reaction mixture was cooled to room temperature
- custompartitioned
- additionby adding water and diethyl ether
- washThe organic layer was washed with water
- dry with materialwith brine, dried over magnesium sulfate anhydride
- customevaporated
- customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate system), whereby the title compound 5.09 g, 81%
- customwas obtained as a colorless oil
出典と根拠
- ORDレコード
- ord-52e14bb41c64470683a42ed6edebce20
- 出典データセット
- uspto-grants-2004_05
- 特許番号
- US06737425B1
反応ノート
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