4-Formyl-1-methyl-1H-pyrrole-2-carbonitrile → 4-(Aminomethyl)-1-methyl-1H-pyrrole-2-carbonitrile
反応式
C(C1N(C)C=C(C=O)C=1)#N.NCC1N(C)C(C#N)=CC=1.[N:21]([CH2:24][C:25]1[CH:26]=[C:27]([C:31]#[N:32])[N:28]([CH3:30])[CH:29]=1)=[N+]=[N-]>>[NH2:21][CH2:24][C:25]1[CH:26]=[C:27]([C:31]#[N:32])[N:28]([CH3:30])[CH:29]=1参加物
4
実験手順
Starting from 5-Cyano-1-methylpyrrole-3-carbaldehyde; 4-aminomethyl-1-methylpyrrole-2-carbonitrile was synthesized analogously to the synthesis of 5-aminomethyl-1-methylpyrrole-2-carbonitrile. However, the 4-azidomethyl-1-methylpyrrole-2-carbonitrile was advantageously reduced in a Staudinger reaction (see S. Nagarajan et al. J. Org. Chem. 1987, 52, 5044-6).
出典と根拠
- ORDレコード
- ord-5eca5078d26e4e588ad1fe1f3b2ff332
- 出典データセット
- uspto-grants-2004_05
- 特許番号
- US06740647B1
反応ノート
読み込み中…