2-Bromothiophene → 2-Chloro-6-methyl-3-(thiophene-2-carbonyl)pyridine

HRID 1582970ノート

反応式

HRID 1582970 の反応式
[Mg].Br[C:3]1[S:4][CH:5]=[CH:6][CH:7]=1.[Cl:8][C:9]1[N:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:10]=1[C:11](O)=[O:12]>C(OCC)C>[Cl:8][C:9]1[C:10]([C:11]([C:3]2[S:4][CH:5]=[CH:6][CH:7]=2)=[O:12])=[CH:14][CH:15]=[C:16]([CH3:18])[N:17]=1

参加物

5

反応物 3

HCID 138512-BromothiopheneHCID 1217242-Chloro-6-methylnicotinic acidHCID 5462224Magnesium

生成物 1

HCID 227167012-Chloro-6-methyl-3-(thiophene-2-carbonyl)pyridine

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
0 °C

実験手順

To a diethyl ether suspension of magnesium was added dropwise 2-bromothiophene at room temperature, and the whole was reacted. After cooling to 0° C., the reaction mixture was added with 2-chloro-6-methylnicotinic acid and, after being warmed to room temperature, the whole was stirred for 12 hours. Thereafter, the reaction mixture was worked up and purified in a usual manner to obtain 2-chloro-6-methyl-3-(thiophene-2-carbonyl)pyridine. NMR1: 7.79 (1H, dd, J=5.0, 1.1 Hz), 7.78 (1H, d, J=7.7 Hz), 2.63 (3H, s).

後処理

  1. customthe whole was reacted
  2. temperatureafter being warmed to room temperature
  3. custompurified in a usual manner

出典と根拠

ORDレコード
ord-d17391885b51489b9a6a73be0ee66e39
出典データセット
uspto-grants-2004_05
特許番号
US06740662B1

反応ノート

読み込み中…