Dimethylamine → HCID 22282638、化合物
反応式
Br[C:2]1[CH:11]=[C:10]([Br:12])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[CH3:13][NH:14][CH3:15]>O>[Br:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=[C:2]([N:14]([CH3:15])[CH3:13])[CH:11]=1参加物
4
実験手順
The product from (451a) (2.0 g, 7.0 mmol) was dissolved in 10 mL of 40% dimethylamine solution in H2O. The reaction mixture was allowed to stir overnight. The solution was diluted to 40 mL with H2O and it was extracted with EtOAc for three times. The combined organic layer was dried over MgSO4. After concentration, the residue was purified on silica gel column to provide 4-bromo-2-dimethylaminoquinoline (451b) (0.69 g, 40%). MS (AP+): 251 (M+1).
後処理
- extractionwas extracted with EtOAc for three times
- dry with materialThe combined organic layer was dried over MgSO4
- concentrationAfter concentration
- customthe residue was purified on silica gel column
出典と根拠
- ORDレコード
- ord-d953b726c1114df48f7b3dd114e2fb1d
- 出典データセット
- uspto-grants-2004_05
- 特許番号
- US06740649B2
反応ノート
読み込み中…