Potassium Iodide → 7-(Pyridin-3-YL)heptanenitrile

HRID 1583421ノート

反応式

HRID 1583421 の反応式
[C-:1]#[N:2].[K+].[I-].[K+].[N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]Cl)[CH:7]=1>CN(C)C=O.O>[N:6]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][C:1]#[N:2])[CH:7]=1

参加物

6

反応物 3

HCID 4875Potassium IodideHCID 9032Potassium CyanideHCID 135575283-(6-Chlorohexyl)pyridine

生成物 1

HCID 137397387-(Pyridin-3-YL)heptanenitrile収率 84.2%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

A mixture of 4.0 g of potassium cyanide, 0.85 g of potassium iodide and 10.1 g of 6-(3-pyridyl)hexyl chloride in 100 ml of dimethylformamide was heated at 100° C. overnight. The reaction mixture was diluted with 200 ml of water and was extracted with dichloromethane. The combined organic layers were washed with water, dried over potassium carbonate and were evaporated. The residue was distilled to give 8.1 g (84%) of 3-pyridine heptanenitrile.

後処理

  1. extractionwas extracted with dichloromethane
  2. washThe combined organic layers were washed with water
  3. dry with materialdried over potassium carbonate
  4. customwere evaporated
  5. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-c3aa296857b643fd97ce27678c121ce5
出典データセット
uspto-grants-1985_11
特許番号
US04551460

反応ノート

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