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Dimethylformamide → 4-(2-Fluoroethoxy)isopropenylbenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Chloro-2-fluoroethane | HCID 12983 | — |
| 反応物 | p-Isopropenylphenol | HCID 584247 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 4-(2-Fluoroethoxy)isopropenylbenzene | HCID 20259265 | 95.7% |
反応手順
To 30 ml of dimethylformamide were added 7.0 g of 4-isopropenylphenol, 6.1 g of 1-fluoro-2-chloroethane and 8.7 g of potassium carbonate. With stirring, they were reacted at 120° C. for 4 hours. The reaction mixture was cooled to room temperature, and poured into water. The mixture was then extracted with toluene. The toluene layer was washed with water and dried over anhydrous sodium sulfate. Toluene was evaporated under reduced pressure to give 9.0 g of crude 4-(2-fluoroethoxy)isopropenylbenzene.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04552894 |
| 出典データセット | uspto-grants-1985_11 |
| ORD ID | ord-c8440b73d64141fe9a53354cfa7b5462 |
| 出典メモ | uspto-grants-1985_11 |