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2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole → 2-Methyl-4-morpholino-5-fluoro-7-bromoindole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole | HCID 20258982 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 2-Methyl-4-morpholino-5-fluoro-7-bromoindole | HCID 20258993 | 65.3% |
反応手順
Raney nickel (400 g) was added to a solution of 58 g of 2-methyl-3-methylthio-4-morpholino-5-fluoro-7-bromoindole in 1 l of dioxane and the mixture was allowed to react at room temperature for 4 hours. After completion of the reaction Raney nickel was removed by filtration, and the filtrate was concentrated under reduced pressure. 33 g of 2-methyl-4-morpholino-5-fluoro-7-bromoindole was obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04552879 |
| 出典データセット | uspto-grants-1985_11 |
| ORD ID | ord-78b4bffbaf9d43c7b1f4e011992d8ec7 |
| 出典メモ | uspto-grants-1985_11 |