2-(2-Nitrophenyl)-3,1-benzoxazin-4-one → 2-(2-aminophenyl)-4H-3,1-benzoxazin-4-one

HRID 1583741ノート

反応式

HRID 1583741 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[O:15][C:14](=[O:16])[C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[N:11]=1)([O-])=O>C(OCC)(=O)C.[Pt]=O>[NH2:1][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[C:10]1[O:15][C:14](=[O:16])[C:13]2[CH:17]=[CH:18][CH:19]=[CH:20][C:12]=2[N:11]=1

参加物

4

反応物 1

HCID 3476752-(2-Nitrophenyl)-3,1-benzoxazin-4-one

生成物 1

HCID 8383952-(2-aminophenyl)-4H-3,1-benzoxazin-4-one

試薬・触媒・溶媒 2

HCID 82844Platinum oxide (PtO)触媒HCID 8857Ethyl Acetate溶媒

実験手順

2-(2-Nitrophenyl)-3,1-benzoxazin-4-one (1.1 g, 4.10 mmole) was suspended in 40 ml of ethyl acetate, with platinum oxide (100 mg) being added, and the resulting reaction mixture was hydrogenated at atmospheric pressure with vigorous stirring. After 3 hours, the catalyst was removed and the solvent was rotoevaporated. The residual yellow oil was subjected to flash chromatography to give a homogeneous product. Recrystallization from acetone provided the analytical sample, m.p. 163°-165° C. (lit.* 162° C.).

後処理

  1. additionbeing added
  2. customthe resulting reaction mixture
  3. customthe catalyst was removed
  4. customto give a homogeneous product
  5. customRecrystallization from acetone
  6. customprovided the analytical sample, m.p. 163°-165° C. (lit.* 162° C.)

出典と根拠

ORDレコード
ord-93673244aa4948aeafe61369154663f8
出典データセット
uspto-grants-1985_11
特許番号
US04554272

反応ノート

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