N-(tert-butoxycarbonyl)glycine → HCID 20258244、化合物

HRID 1583742ノート

反応式

HRID 1583742 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:13][C:12](=[O:14])[C:11]2[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=2[N:9]=1.[C:19]([O:23][C:24]([NH:26][CH2:27][C:28](O)=[O:29])=[O:25])([CH3:22])([CH3:21])[CH3:20]>>[C:19]([O:23][C:24]([NH:26][CH2:27][C:28]([NH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[O:13][C:12](=[O:14])[C:11]2[CH:15]=[CH:16][CH:17]=[CH:18][C:10]=2[N:9]=1)=[O:29])=[O:25])([CH3:22])([CH3:21])[CH3:20]

参加物

3

反応物 2

HCID 78288N-(tert-butoxycarbonyl)glycineHCID 8383952-(2-aminophenyl)-4H-3,1-benzoxazin-4-one

生成物 1

HCID 20258244HCID 20258244、化合物

実験手順

Using identical reaction conditions as described for the synthesis of the compounds of formula VII of Scheme 2 above, 480 mg (2.0 mmole) of 2-(2-aminophenyl)-3,1-benzoxazin-4-one was reacted with 525 mg (3.0 mmole) of tert-butyloxycarbonylglycine to give 170 mg of the chromatographically-homogeneous tilted compound in 60% overall yield after three cycles.

後処理

  1. customreaction conditions
  2. customto give 170 mg of the
  3. customoverall yield after three cycles

出典と根拠

ORDレコード
ord-246ab69e470f453ba6ac0a497e68561e
出典データセット
uspto-grants-1985_11
特許番号
US04554272

反応ノート

読み込み中…