化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Fluoride → 3-Bromo-4-fluorobenzoyl fluoride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Fluoride | HCID 5235 | — |
| 反応物 | Potassium Fluoride | HCID 522689 | — |
| 反応物 | 3-Bromo-4-chlorobenzoyl chloride | HCID 20229730 | — |
| 溶媒 | Sulfolane | HCID 31347 | — |
| 生成物 | 3-Bromo-4-fluorobenzoyl fluoride | HCID 12922707 | 79% |
反応手順
1,270 g (5 moles) of 4-chloro-3-bromo-benzoyl chloride, 1,150 g of tetramethylenesulphone and 315 g (7.5 moles) of anhydrous sodium fluoride were warmed for 5 hours to 210° C., while stirring. Thereafter, 435 g (7.5 moles) of anhydrous potassium fluoride, suspended in 1,150 g of tetramethylenesulphone, were added to the reaction mixture, and the latter was stirred for a further 7 hours at 210° C. The subsequent distillation gave 873 g (79% of theory) of 4-fluoro-3-bromobenzoyl fluoride (a starting material for Example 19).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04555370 |
| 出典データセット | uspto-grants-1985_11 |
| ORD ID | ord-b653fc85bcfd4c4fa2e93031028595c4 |
| 出典メモ | uspto-grants-1985_11 |