1-Bromohexadecane → HCID 13076757、化合物

HRID 1583919ノート

反応式

HRID 1583919 の反応式
[C:1]([C:5]1[C:14]([OH:15])=[CH:13][C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+].[CH2:22](Br)[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37]>CN(C)C=O>[C:1]([C:5]1[C:14]([O:15][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH3:22])=[CH:13][C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 82131-BromohexadecaneHCID 11430Potassium CarbonateHCID 12886750HCID 12886750、化合物

生成物 1

HCID 13076757HCID 13076757、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

6.9 g of the benzoxazole derivative obtained in Step (c) above was dissolved in 50 ml of dimethylformamide and the solution was stirred at 80° to 90° C. for 6 hours together with 8 g of anhydrous potassium carbonate and 11 g of hexadecyl bromide. After the completion of the reaction, the insoluble material was removed by filtration. To the filtrate was added 150 ml of methanol and the mixture was cooled with ice to precipitate crystals. The crystals were collected by filtration, thus obtained 8.8 g (62%) yield) of 6-tert-butyl-5-hexadecyloxy-2-methylbenzoxazole.

後処理

  1. customAfter the completion of the reaction
  2. customthe insoluble material was removed by filtration
  3. additionTo the filtrate was added 150 ml of methanol
  4. temperaturethe mixture was cooled with ice
  5. customto precipitate crystals
  6. filtrationThe crystals were collected by filtration, thus obtained 8.8 g (62%)

出典と根拠

ORDレコード
ord-de0d5940eb88473c8abcbf0953c28cc7
出典データセット
uspto-grants-1985_11
特許番号
US04555470

反応ノート

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