Hydrochloric Acid → 2-Amino-4-phenylbutyrate ethyl hydrochloride

HRID 1583948

反応式

HRID 1583948 の反応式
[NH2:1][CH:2]([C:11]([OH:13])=[O:12])[CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[ClH:14].[CH2:15](O)[CH3:16]>>[ClH:14].[NH2:1][CH:2]([CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)[C:11]([O:13][CH2:15][CH3:16])=[O:12]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 102530Homophenylalanine, DL-

生成物 1

HCID 533952832-Amino-4-phenylbutyrate ethyl hydrochloride

実験手順

A suspension of d,l-homophenylalanine (5 g., 27.9 mmole) in absolute ethanol (60 ml.) was cooled to 0° (ice bath) and saturated with hydrochloric acid gas. The mixture was allowed to warm to room temperature and stirred overnight. A stream of nitrogen was then passed through the solution to remove the bulk of the hydrochloric acid and the mixture was evaporated to dryness. The solid residue was triturated with ether, filtered and dried to give (±)-α-aminobenzenebutanoic acid, ethyl ester, monohydrochloride as a fluffy white solid; m.p. 129°-130°. Rf (acetic acid/methanol/dichloromethane; 1:1:8)=0.63.

後処理

  1. temperaturewas cooled to 0° (ice bath)
  2. customto remove the bulk of the hydrochloric acid
  3. customthe mixture was evaporated to dryness
  4. customThe solid residue was triturated with ether
  5. filtrationfiltered
  6. customdried

出典と根拠

ORDレコード
ord-b4b9aae2b2e54730a8980873ba7da2f8
出典データセット
uspto-grants-1985_11
特許番号
US04555506

関連ノート

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