Acetic Anhydride → N-[(6-Methoxypyridin-2-yl)methyl]acetamide
反応式
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[N:4]=1)#[N:2].[C:11]([O-])(=[O:13])[CH3:12].[Na+].C(OC(=O)C)(=O)C>[Ni]>[C:11]([NH:2][CH2:1][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([O:9][CH3:10])[N:4]=1)(=[O:13])[CH3:12]参加物
5
実験手順
A mixture of 1.0 g (7.46 mmole) of 2-cyano-6-methoxypyridine, 0.37 g (4.48 mmole) of sodium acetate, 25 ml of acetic anhydride and about 1.0 g of Raney nickel was hydrogenated on a Parr apparatus for about 5.5 hours. The mixture was filtered, and then evaporated with warming in vacuo to provide 2-acetamidomethyl-6-methoxypyridine. The structural assignment was supported by infrared spectral analysis.
後処理
- filtrationThe mixture was filtered
- customevaporated
- temperaturewith warming in vacuo
出典と根拠
- ORDレコード
- ord-0c3659fc96d14b36940feb62517e1d91
- 出典データセット
- uspto-grants-1985_11
- 特許番号
- US04555573
反応ノート
読み込み中…