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N,N-Dimethylaniline → 1,6-dichloro-7-methoxy-4-nitro-9(10H)-acridinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N-Dimethylaniline | HCID 949 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 6-Chloro-2-[(3-chloro-4-methoxyphenyl)amino]-3-nitrobenzoic acid | HCID 13588347 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | 1,6-dichloro-7-methoxy-4-nitro-9(10H)-acridinone | HCID 13588331 | — |
反応手順
A mixture of 17 g of 6-chloro-2-[(3-chloro-4-methoxyphenyl)amino]-3-nitrobenzoic acid, 35 ml of phosphorus oxychloride, 1 ml of N,N-dimethylaniline and 150 ml 1,2-dichloroethane was heated under reflux for 45 minutes. The resulting solid was collected by filtration from the hot reaction mixture and was washed with chloroform to provide 1,6-dichloro-7-methoxy-4-nitro-9(10H)-acridinone, mp 284°-285° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04555572 |
| 出典データセット | uspto-grants-1985_11 |
| ORD ID | ord-78590ad93ba54956a2bab90ca6646016 |
| 出典メモ | uspto-grants-1985_11 |