HCID 54273654、化合物 → HCID 53896857、化合物
反応式
[CH3:1][O:2][C:3]1[CH:24]=[C:23]([C:25]#[N:26])[CH:22]=[CH:21][C:4]=1[CH2:5][NH:6][C:7](=[O:20])[C@@H:8]1[CH2:12][CH2:11][CH2:10][N:9]1C(OC(C)(C)C)=O>C(Cl)Cl>[CH3:1][O:2][C:3]1[CH:24]=[C:23]([C:25]#[N:26])[CH:22]=[CH:21][C:4]=1[CH2:5][NH:6][C:7](=[O:20])[C@@H:8]1[CH2:12][CH2:11][CH2:10][NH:9]1参加物
3
実験手順
11.4 g (31.7 mmol) of Boc-proline 2-methoxy-4-cyanobenzylamide were dissolved in 130 ml of methylene chloride and, at 0-5° C., saturated with HCI [sic]. After 2 h the Boc group had been completely eliminated. The solvent was removed under reduced pressure, and the product was used without further purification in the next reaction. 1H-NMR (DMSO-d6 ; δ in ppm): 10.25 (s, 1H); 8.60 (s, 1H); 7.50 (d, 1H; 7.42 (dd, 1H); 7.39 (d, 1); 4.40-4.20 (m, 3H); 3.88 (s, 3H); 3.20 (m, 2H); 2.35 (m, 1H); 2.00-1.80 (m, 3H)
後処理
- customThe solvent was removed under reduced pressure
- customthe product was used without further purification in the next reaction