Hydrochloric Acid → 1,2,3,4-Tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide hydrochloride

HRID 1584269ノート

反応式

HRID 1584269 の反応式
[C:1]([C:3]1[CH:36]=[CH:35][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][NH:15][C:16]([C@@H:18]3[CH2:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH2:20][N:19]3C(OC(C)(C)C)=O)=[O:17])=[CH:11][N:10]=[CH:9]2)=[CH:5][CH:4]=1)#[N:2].[ClH:37]>CCOC(C)=O>[ClH:37].[C:1]([C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[C:12]([CH2:13][CH2:14][NH:15][C:16]([C@@H:18]3[CH2:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[CH2:20][NH:19]3)=[O:17])=[CH:11][N:10]=[CH:9]2)=[CH:35][CH:36]=1)#[N:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 701032202-(t-Butyloxycarbonyl)-1,2,3,4-tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide

生成物 1

HCID 701220621,2,3,4-Tetrahydro-isoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide hydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

反応条件

温度
25 °C

実験手順

A solution of 2-(t-butyloxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3(S)-carboxylic acid {2-[3-(4-cyanobenzyl)-3H-imidazol-4-yl]-ethyl}-amide (0.25 g, 0.52 mmol) in EtOAc (15 mL) was cooled to -20° C. The solution was saturated with HCl gas and stirred at 0° C. for 0.5 hr and 25° C. for an additional 0.5 hr. The reaction was evaporated in vacuo to obtain the title compound which was used without further purification.

後処理

  1. customThe reaction was evaporated in vacuo

出典と根拠

ORDレコード
ord-3499189afff04f018e0f1f99021e9a43
出典データセット
uspto-grants-1999_08
特許番号
US05932590

反応ノート

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