Hydrochloric Acid → Ethyl 2-hydroxy-4-(4-hydroxy-3-methoxyphenyl)butanoate

HRID 1584361ノート

反応式

HRID 1584361 の反応式
C([O:4][CH:5]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([O:16]CC2N=C(C3C=CC=CC=3)OC=2C)=[C:12]([O:30][CH3:31])[CH:11]=1)[C:6]#N)(=O)C.Cl.[O:33]1CCO[CH2:35][CH2:34]1.[OH2:39]>>[OH:4][CH:5]([CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[C:12]([O:30][CH3:31])[CH:11]=1)[C:6]([O:33][CH2:34][CH3:35])=[O:39]

参加物

5

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 312751,4-DioxaneHCID 212244242-Acetoxy-4-[3-methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]butyronitrile

生成物 1

HCID 21224421Ethyl 2-hydroxy-4-(4-hydroxy-3-methoxyphenyl)butanoate収率 60%

実験手順

A mixture of 2-acetoxy-4-[3-methoxy-4-(5-methyl-2-phenyl-4-oxazolylmethoxy)phenyl]butyronitrile (2.0 g), 6 N HCl (24 ml) and dioxane (12 ml) was stirred for 4 hours under reflux. The reaction mixture was poured into water, which was subjected to extraction with ethyl acetate. The ethyl acetate layer was washed with water and dried (MgSO4), followed by distilling off the solvent. To the resulting oily product was added ethanolic hydrochloric acid (10%, 24 ml), followed by stirring for 1.5 hours under reflux. The reaction mixture was poured into water, which was subjected to extraction with ethyl acetate. The ethyl acetate layer was washed with water, dried (MgSO4), followed by distilling off the solvent. The resulting oily product was subjected to column chromatography on silica gel. From the fraction eluted with ethyl acetate-hexane (1:2, v/v), was obtained ethyl 2-hydroxy-4-(4-hydroxy-3-methoxyphenyl)butanoate (0.73 g, 60%),

後処理

  1. temperatureunder reflux
  2. extractionwas subjected to extraction with ethyl acetate
  3. washThe ethyl acetate layer was washed with water
  4. dry with materialdried (MgSO4)
  5. distillationby distilling off the solvent
  6. additionTo the resulting oily product was added ethanolic hydrochloric acid (10%, 24 ml)
  7. stirringby stirring for 1.5 hours
  8. temperatureunder reflux
  9. additionThe reaction mixture was poured into water, which
  10. extractionwas subjected to extraction with ethyl acetate
  11. washThe ethyl acetate layer was washed with water
  12. dry with materialdried (MgSO4)
  13. distillationby distilling off the solvent
  14. washFrom the fraction eluted with ethyl acetate-hexane (1:2

出典と根拠

ORDレコード
ord-98a2914ddded40668da0be361a3fe5cc
出典データセット
uspto-grants-1999_08
特許番号
US05932601

反応ノート

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