Isopropanol → 4-(1-(2-(fur-2-ylmethoxy)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane

HRID 1584454ノート

反応式

HRID 1584454 の反応式
C(OC([N:6]1[CH2:12][CH2:11][CH2:10][N:9]([C:13]2[N:17]([CH2:18][CH2:19][O:20][CH2:21][C:22]3[O:23][CH:24]=[CH:25][CH:26]=3)[C:16]3[CH:27]=[CH:28][CH:29]=[CH:30][C:15]=3[N:14]=2)[CH2:8][CH2:7]1)=O)C.[OH-].[K+].C(O)(C)C>O>[O:23]1[CH:24]=[CH:25][CH:26]=[C:22]1[CH2:21][O:20][CH2:19][CH2:18][N:17]1[C:16]2[CH:27]=[CH:28][CH:29]=[CH:30][C:15]=2[N:14]=[C:13]1[N:9]1[CH2:10][CH2:11][CH2:12][NH:6][CH2:7][CH2:8]1

参加物

5

反応物 3

HCID 3776IsopropanolHCID 14797Potassium HydroxideHCID 212236281-ethoxycarbonyl-4-(1-(2-(fur-2-ylmethoxy)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane

生成物 1

HCID 212235564-(1-(2-(fur-2-ylmethoxy)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Combine 1-ethoxycarbonyl-4-(1-(2-(fur-2-ylmethoxy)ethyl)-1H-benzimidazol-2-yl)[1,4]diazepane (1 mmol), potassium hydroxide (1.2 mmol), and isopropanol (20 mL). Heat to reflux. After 18 hours, evaporate in vacuo to give a residue. Combine the residue and water. Extract with dichloromethane. Dry the organic layer over MgSO4, filter, and evaporate in vacuo to give the title compound.

後処理

  1. temperatureHeat to reflux
  2. customevaporate in vacuo
  3. customto give a residue
  4. extractionExtract with dichloromethane
  5. dry with materialDry the organic layer over MgSO4
  6. filtrationfilter
  7. customevaporate in vacuo

出典と根拠

ORDレコード
ord-d9847c63aa724956a7f5554a0e347ac1
出典データセット
uspto-grants-1999_08
特許番号
US05932571

反応ノート

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