Piperidine → 4-Chloro-1-(piperidin-1-yl)butan-1-one
反応式
[Cl:1][CH2:2][CH2:3][CH2:4][C:5](Cl)=[O:6].[NH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.C(N(CC)CC)C>ClCCl>[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:6]参加物
5
実験手順
4-Chlorobutyryl chloride in dichlormethane was added to an ice cooled solution of piperidine (1.8 ml; 17.6 mmol) and triethylamine (2.5 ml) in dichloromethane (40 ml) under an atmosphere of nitrogen. The mixture was stirred for 5 min whilst being cooled, then stirred at ambient temperature for 3 h. The solution was washed with water, dried over sodium sulfate and evaporated to give 1-(4-chloro-1-oxobutyl)piperidine as a pale yellow oil (2.1 g).
後処理
- temperaturewhilst being cooled
- stirringstirred at ambient temperature for 3 h
- washThe solution was washed with water
- dry with materialdried over sodium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-891d443741d64ed497ff037d8fccf181
- 出典データセット
- uspto-grants-1999_08
- 特許番号
- US05935974
反応ノート
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