Water → HCID 21220308、化合物

HRID 1584816ノート

反応式

HRID 1584816 の反応式
[Br:1][C:2]1[C:20]([F:21])=[CH:19][C:5]([C:6]([C:8](=[CH:14][NH:15][CH:16]2[CH2:18][CH2:17]2)[C:9]([O:11][CH2:12][CH3:13])=[O:10])=[O:7])=[C:4](F)[C:3]=1[CH3:23].C(=O)([O-])[O-].[K+].[K+].O>CS(C)=O>[Br:1][C:2]1[C:3]([CH3:23])=[C:4]2[C:5]([C:6](=[O:7])[C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:14][N:15]2[CH:16]2[CH2:18][CH2:17]2)=[CH:19][C:20]=1[F:21]

参加物

5

反応物 3

HCID 962WaterHCID 11430Potassium CarbonateHCID 178471861HCID 178471861、化合物

生成物 1

HCID 21220308HCID 21220308、化合物

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
100 °C

実験手順

In 175 ml of dimethyl sulfoxide was dissolved 35.0 g of ethyl 2-(4-bromo-2,5-difluoro-3-methylbenzoyl)-3-cyclopropylaminoacrylate, and 27.4 g of potassium carbonate was added to the solution, after which the resulting mixture was stirred at 100° C. for 30 minutes. The reaction mixture was cooled to room temperature, and 1,000 ml of water was then added thereto, after which the crystals formed were collected by filtration, to obtain 30.0 g of colorless, crystalline ethyl 7-bromo-1-cyclopropyl-6-fluoro-8-methyl-1,4-dihydro-4-oxoquinoline-3-carboxylate.

後処理

  1. additionwas added to the solution
  2. temperatureThe reaction mixture was cooled to room temperature
  3. customafter which the crystals formed
  4. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-ff799f89d2c648c1a90fc65a51119b63
出典データセット
uspto-grants-1999_08
特許番号
US05935952

反応ノート

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