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Hydrochloric Acid → Ethyl 7-bromo-1-cyclopropyl-6-fluoro-8-hydroxymethyl-1,4-dihydro-4-oxoquinoline-3-carboxylate

HRID 1584817
ノート
印刷プレビュー

反応式

HRID 1584817 の反応式
C([O:4][CH2:5][C:6]1[C:7]([Br:26])=[C:8]([F:25])[CH:9]=[C:10]2[C:15]=1[N:14]([CH:16]1[CH2:18][CH2:17]1)[CH:13]=[C:12]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[C:11]2=[O:24])(=O)C.C[O-].[Na+].O.Cl>C(O)C>[Br:26][C:7]1[C:6]([CH2:5][OH:4])=[C:15]2[C:10]([C:11](=[O:24])[C:12]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[CH:13][N:14]2[CH:16]2[CH2:18][CH2:17]2)=[CH:9][C:8]=1[F:25]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 10942334Sodium MethoxideHCID 21220351HCID 21220351、化合物

生成物 1

HCID 21220404Ethyl 7-bromo-1-cyclopropyl-6-fluoro-8-hydroxymethyl-1,4-dihydro-4-oxoquinoline-3-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In 58 ml of ethanol was suspended 1.46 g of ethyl 8-acetoxymethyl-7-bromo-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylate, and 19 mg of sodium methoxide was added to the suspension, after which the resulting mixture was stirred at room temperature for seven hours. To the reaction mixture was added 60 ml of water and the pH was adjusted to 7 with 1N hydrochloric acid, after which the crystals formed were collected by filtration, to obtain 1.28 g of colorless, crystalline ethyl 7-bromo-1-cyclopropyl-6-fluoro-8-hydroxymethyl-1,4-dihydro-4-oxoquinoline-3-carboxylate.

後処理

  1. additionwas added to the suspension
  2. customafter which the crystals formed
  3. filtrationwere collected by filtration

出典と根拠

ORDレコード
ord-8fbafc71836c47dba1b113b8cfc4330b
出典データセット
uspto-grants-1999_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05935952

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート