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Dimethyl-1,3-thiazole-5-carboxylic acid → 2,4-Dimethyl-N-(3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1,3-thiazole-5-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethyl-1,3-thiazole-5-carboxylic acid | HCID 736488 | — |
| 反応物 | 3-{1-Methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline | HCID 57444335 | — |
| 生成物 | 2,4-Dimethyl-N-(3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1,3-thiazole-5-carboxamide | HCID 57478356 | 87% |
反応手順
The title compound was prepared in 87% yield according to the general procedure for the preparation of amides (Method C) starting from 3-{1-methyl-2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (D21) and 2,4-dimethyl-1,3-thiazole-5-carboxylic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732600B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-5764fb485590493b92ea7889bc80ad77 |
| 出典メモ | uspto-grants-2010_06 |