Hydrogen Peroxide → 1-Benzoyl-1,2-dihydroquinoline-2-carboxamide

HRID 1585568ノート

反応式

HRID 1585568 の反応式
[C:1]([N:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]1[C:19]#[N:20])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)(O)[O-:22].[Na+].OO>CC(C)=O>[C:1]([N:9]1[C:18]2[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:12]=[CH:11][CH:10]1[C:19]([NH2:20])=[O:22])(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 784Hydrogen PeroxideHCID 262192-Quinolinecarbonitrile, 1,2-dihydro-1-benzoyl-HCID 516892Sodium Bicarbonate

生成物 1

HCID 2304901-Benzoyl-1,2-dihydroquinoline-2-carboxamide収率 55%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

1-(Benzoyl)-1,2-dihydro-quinoline-2-carbonitrile (26.0 g) was dissolved in acetone (500 mL). Solid sodium bicarbonate (15 g) was added. The mixture was stirred for 30 minutes. 30% Hydrogen peroxide solution (250 mL of a 30% solution) was added drop-wise. After stirring for 4 hours, the acetone was evaporated under vacuum. The residue was acidified with 1N HCl. The precipitate was collected, washed with water and air dried. The solid was slurried in ether then filtered. The title compound (15.3 g) was obtained as an off-white solid, m.p. 169-171° C.

後処理

  1. stirringAfter stirring for 4 hours
  2. customthe acetone was evaporated under vacuum
  3. customThe precipitate was collected
  4. washwashed with water and air
  5. customdried
  6. filtrationthen filtered

出典と根拠

ORDレコード
ord-8a21f88e4da84c838575a2c8ae2a96a0
出典データセット
uspto-grants-1999_08
特許番号
US05939435

反応ノート

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