HCID 21696991、化合物 → HCID 9823286、化合物

HRID 1585904ノート

反応式

HRID 1585904 の反応式
[OH:1][C:2]1[CH:9]=[C:8]([CH2:10][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].Br[CH2:17][C:18]1[CH:19]=[CH:20][C:21]([N:24]2[CH:29]=[C:28]([Cl:30])[CH:27]=[CH:26][C:25]2=[O:31])=[N:22][CH:23]=1>CN(C=O)C>[Cl:30][C:28]1[CH:27]=[CH:26][C:25](=[O:31])[N:24]([C:21]2[CH:20]=[CH:19][C:18]([CH2:17][O:1][C:2]3[CH:9]=[C:8]([CH2:10][N:11]4[CH:15]=[CH:14][N:13]=[CH:12]4)[CH:7]=[CH:6][C:3]=3[C:4]#[N:5])=[CH:23][N:22]=2)[CH:29]=1

参加物

4

反応物 2

HCID 21696991HCID 21696991、化合物HCID 216970282-Hydroxy-4-imidazol-1-ylmethyl-benzonitrile

生成物 1

HCID 9823286HCID 9823286、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

2-Hydroxy 4-imidazol-1-ylmethyl-benzonitrile (0.050 g, 0.25 mmol) and 5'-bromomethyl-5-chloro-[1,2']bipyridinyl-2-one (Example 10 Step 2) (0.079 g, 0.262 mmol) were dissolved in dry DMF (5 mL), treated with CsCO3 (0.123 g, 0.376 mmol) and stirred at ambient temperature for 18 hr. The reaction mixture was partitioned between EtOAc and aqueous satd NaHCO3 solution, the organic layer washed with H2O, brine, and dried (MgSO4). Chromatography (SiO2, 1-4% CH3OH in CH2Cl2) gave the title compound.

後処理

  1. customThe reaction mixture was partitioned between EtOAc and aqueous satd NaHCO3 solution
  2. washthe organic layer washed with H2O, brine
  3. dry with materialdried (MgSO4)

出典と根拠

ORDレコード
ord-03e0eeb813ac4be2a869433f1a6d05e4
出典データセット
uspto-grants-1999_08
特許番号
US05939439

反応ノート

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