Water → Ethyl 3-(2-bromophenyl)-2-methylpropionate

HRID 1585972ノート

反応式

HRID 1585972 の反応式
[Br:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][C:5](C)([C:11](OCC)=O)[C:6]([O:8][CH2:9][CH3:10])=[O:7].[Cl-].[Li+].O>CS(C)=O>[Br:1][C:2]1[CH:20]=[CH:19][CH:18]=[CH:17][C:3]=1[CH2:4][CH:5]([CH3:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

参加物

5

反応物 3

HCID 962WaterHCID 433294Lithium ChlorideHCID 21217385Diethyl 2-(2-bromobenzyl)-2-methylmalonate

生成物 1

HCID 21217380Ethyl 3-(2-bromophenyl)-2-methylpropionate収率 100.1%

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
180 °C

実験手順

To a solution of diethyl 2-(2-bromobenzyl)-2-methylmalonate (108 g, 310 mmole) in dimethylsulfoxide (350 ml) were added 26.4 g of lithium chloride (620 mmole) and 5.6 ml of water (310 mmole). After stirring at 180° C. for 8 hours, the product was extracted with n-hexane and concentrated to give 84.1 g of ethyl 3-(2-bromophenyl)-2-methylpropionate as a yellow oil (yield, 100%).

後処理

  1. extractionthe product was extracted with n-hexane
  2. concentrationconcentrated
  3. customto give

出典と根拠

ORDレコード
ord-8d3aa1d4cc0c4858b4e0abb7a6c4038e
出典データセット
uspto-grants-1999_08
特許番号
US05942459

反応ノート

読み込み中…