4-Hydroxy-N-methylcarbostyril → 1-methyl-3-dimethylaminomethylene-(1H)-quinolin-2,4-dione
反応式
[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([OH:12])=[CH:4][C:3]1=[O:13]>COC(OC)N(C)C.C(Cl)Cl>[CH3:1][N:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5](=[O:12])[C:4](=[CH:1][N:2]([CH3:11])[CH3:3])[C:3]1=[O:13]参加物
4
実験手順
A suspension of 1-methyl-4-hydroxy-2(1H)-quinolinone (1.0 gm) in dimethyl formamide dimethyl acetal (5 ml) and methylene chloride (2.0) was refluxed for 1 hour. The resulting dark orange solution was evaporated under reduced pressure to give 1-methyl-3-dimethylaminomethylene-(1H)-quinolin-2,4-dione.
後処理
- temperaturewas refluxed for 1 hour
- customThe resulting dark orange solution was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-5f3a514aaa8e4393921c6d4682d0cc90
- 出典データセット
- uspto-grants-1999_08
- 特許番号
- US05942522
反応ノート
読み込み中…