Ammonia → (2S,3S)-2 ethyl-3-hydroxybutyramide

HRID 1586299ノート

反応式

HRID 1586299 の反応式
[CH2:1]([C@@H:3]([C@@H:9]([OH:11])[CH3:10])[C:4](OCC)=[O:5])[CH3:2].[NH3:12]>C(O)C>[CH2:1]([C@@H:3]([C@@H:9]([OH:11])[CH3:10])[C:4]([NH2:12])=[O:5])[CH3:2]

参加物

4

反応物 2

HCID 222AmmoniaHCID 13215287(2S,3S)-Ethyl 2 ethyl-3-hydroxybutyrate

生成物 1

HCID 11829477(2S,3S)-2 ethyl-3-hydroxybutyramide収率 85.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

(2S,3S)-Ethyl 2 ethyl-3-hydroxybutyrate (1 gram) is dissolved in 5 ml of absolute ethanol followed by the addition of 0.5 gram of gaseous ammonia. The solution is kept in a stoppered flask, and the progress of the reaction is followed by thin layer chromatography. After the reaction is judged complete, the ethanol is evaporated and the resulting residue redissolved in ethyl acetate. Ammonia is removed by extraction with 1% HCl, and the ethyl acetate solution is dried over MgSO4, filtered, and rotary evaporated to leave 0.7 grams of (2S,3S)-2 ethyl-3-hydroxybutyramide.

後処理

  1. customThe solution is kept in a stoppered flask
  2. customthe ethanol is evaporated
  3. dissolutionthe resulting residue redissolved in ethyl acetate
  4. customAmmonia is removed by extraction with 1% HCl
  5. dry with materialthe ethyl acetate solution is dried over MgSO4
  6. filtrationfiltered
  7. customrotary evaporated

出典と根拠

ORDレコード
ord-8ad26da8a07a40f5a378a9c9369f7788
出典データセット
uspto-grants-1999_08
特許番号
US05942644

反応ノート

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