2-(chloromethyl)-N,N-dimethylaniline → HCID 14064662、化合物

反応式

Cl.[NH2:2][C:3]1[C:12](CCl)=[CH:11][CH:10]=[CH:9][C:4]=1C(OC)=O.[NH2:15][C:16]1[C:25]([CH2:26][S:27]([CH3:29])=O)=[CH:24][CH:23]=[CH:22][C:17]=1[C:18]([O:20][CH3:21])=[O:19].ClCC1C=CC=CC=1[N:34](C)C>C(O)(C)C>[NH2:15][C:16]1[C:25]([CH2:26][S:27][C:29]2[NH:2][C:3]3[CH:12]=[CH:11][CH:10]=[CH:9][C:4]=3[N:34]=2)=[CH:24][CH:23]=[CH:22][C:17]=1[C:18]([O:20][CH3:21])=[O:19]

参加物

実験手順

The title compound was prepared by the method of Example 1 using 1.27 g of methyl 2-amino-3-(chloromethyl)benzoate hydrochloride (prepared from methyl 2-amino-3-(methylsulfinylmethyl)benzoate as reported by J. P. Chupp et al., J. Org. Chem., 49, 4711 (1984) instead of 2-(chloromethyl)-N,N-dimethylaniline in isopropyl alcohol. Recrystallization of the title compound from diethyl ether gave 1.72 g of the title compound in three crops. Anal. Calc'd. for C16H15N3O2S: C, 61.32; H, 4.82; N,13.41; S, 10.23. Found: C, 60.73; H, 4.86; N, 12.87; S, 9.67.