C([O:4][CH2:5][CH2:6][O:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([NH2:13])=[O:12])(=O)C.CNC.N1CCOCC1.C(S)C.OC(CO)COC1C=C(C=CC=1)C(N)=O.CN(CC(O)COC1C=C(C=CC=1)C(N)=O)C.O1CCN(CC(O)COC2C=C(C=CC=2)C(N)=O)CC1.COCC(O)COC1C=C(C=CC=1)C(N)=O.C(SCC(O)COC1C=C(C=CC=1)C(N)=O)C>CO>[OH:4][CH2:5][CH2:6][O:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=1)[C:11]([NH2:13])=[O:12]
In an analogous manner, but effecting lysis of the epoxide ring in the 3-(2,3-epoxy-n-propoxy)benzamide of Example 3, B, using aqueous solution, dimethylamine, morpholine, methanol, or ethyl mercaptan, the corresponding compounds of the invention--3-(2,3-dihydroxy-n-propoxy)benzamide, 3-(3-(N,N-dimethylamino)-2-hydroxy-n-propoxy)benzamide, 3-(3-morpholino-2-hydroxy-n-propoxy)benzamide, 3-(3-methoxy-2-hydroxy-n-propoxy)benzamide, and 3-(3-ethylthio-2-hydroxy-n-propoxy)benzamide--are prepared.
読み込み中…
