Bromine → 2-Bromo-7-nitro-3,4-dihydronaphthalen-1(2H)-one

HRID 1586710ノート

反応式

HRID 1586710 の反応式
[N+:1]([C:4]1[CH:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][C:11]2=[O:14])=[CH:6][CH:5]=1)([O-:3])=[O:2].[Br:15]Br>CCOCC>[Br:15][CH:10]1[CH2:9][CH2:8][C:7]2[C:12](=[CH:13][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=2)[C:11]1=[O:14]

参加物

4

反応物 2

HCID 24408BromineHCID 384457-Nitro-1-tetralone

生成物 1

HCID 131941302-Bromo-7-nitro-3,4-dihydronaphthalen-1(2H)-one

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a suspension of 9.56 g (0.05 mol) of 7-nitro-1-tetralone in 250 mL of ether was added bromine dropwise. The progress of the reaction was followed by thin layer chromatography (fl. silica gel/CH2Cl2). When all of the starting material had been consumed, the mixture was concentrated and cyclohexane was added. The white solid was removed by filtration to afford 2.25 g of 2-bromo-7-nitrotetralone, mp 94°-96° C.

後処理

  1. customWhen all of the starting material had been consumed
  2. concentrationthe mixture was concentrated
  3. additioncyclohexane was added
  4. customThe white solid was removed by filtration

出典と根拠

ORDレコード
ord-26043992f42145718bf92943cdc23514
出典データセット
uspto-grants-1993_06
特許番号
US05215989

反応ノート

読み込み中…