4-Fluorobenzoyl chloride → 2-(4-Fluorophenyl)-6-hydroxybenzothiazole

HRID 1586885ノート

反応式

HRID 1586885 の反応式
NC1C=CC(OC)=CC=1S.FC1C=CC(C(Cl)=O)=CC=1.[F:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[S:29][C:30]3[CH:36]=[C:35]([O:37]C)[CH:34]=[CH:33][C:31]=3[N:32]=2)=[CH:24][CH:23]=1>>[F:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[S:29][C:30]3[CH:36]=[C:35]([OH:37])[CH:34]=[CH:33][C:31]=3[N:32]=2)=[CH:26][CH:27]=1

参加物

4

反応物 3

HCID 678794-Fluorobenzoyl chlorideHCID 2355092-Amino-5-methoxybenzene-1-thiolHCID 121799872-(4-Fluorophenyl)-6-methoxy-1,3-benzothiazole

生成物 1

HCID 167341662-(4-Fluorophenyl)-6-hydroxybenzothiazole

実験手順

The procedure set out in Example 7 is repeated using 2-amino-5-methoxybenzenethiol and 4-fluorobenzoyl chloride. The reaction yields a mixture of the title compound and 2-(4-fluorophenyl)-6-methoxybenzothiazole. The mixture is treated with excess boiling 48 percent HBr for one hour to convert the latter product to the title compound. The solution is filtered and the precipitate is recrystallized from ethanol and water. The overall yield is 80.3 percent based on the initial amount of benzenethiol. A recrystallized product melts at about 221° C.-223° C.

後処理

  1. customThe reaction yields

出典と根拠

ORDレコード
ord-51a11d9d083849aa852cccff0eeedb65
出典データセット
uspto-grants-1993_06
特許番号
US05216110

反応ノート

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