Triethylamine → 2-Methylaminocarbonylamino-4-trichloromethylpyridine

HRID 1587007ノート

反応式

HRID 1587007 の反応式
[CH3:1][N:2]=[C:3]=[O:4].C(N(CC)CC)C.[NH2:12][C:13]1[CH:18]=[C:17]([C:19]([Cl:22])([Cl:21])[Cl:20])[CH:16]=[CH:15][N:14]=1>C1(C)C=CC=CC=1>[CH3:1][NH:2][C:3]([NH:12][C:13]1[CH:18]=[C:17]([C:19]([Cl:21])([Cl:20])[Cl:22])[CH:16]=[CH:15][N:14]=1)=[O:4]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 12228Methyl IsocyanateHCID 137101174-(Trichloromethyl)pyridin-2-amine

生成物 1

HCID 151568352-Methylaminocarbonylamino-4-trichloromethylpyridine収率 82%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

17 ml (0.3 mol) of methyl isocyanate and 1 ml of triethylamine were added to 21.2 g (0.1 mol) of 2-amino-4-trichloromethylpyridine and 400 ml of toluene at 25° C. After 4 hours at 80° C., the resulting solid was isolated. 21.8 g (82%) of the desired product were obtained. Mp.: 192°-195° C.; Active Ingredient Example 2.001

後処理

  1. customthe resulting solid was isolated

出典と根拠

ORDレコード
ord-fb2afe49b8e34711b456079b31f2b18d
出典データセット
uspto-grants-1993_06
特許番号
US05216171

反応ノート

読み込み中…