Tributylstannane → (E)-3-(tributylstannyl)prop-2-en-1-ol

HRID 1587015ノート

反応式

HRID 1587015 の反応式
[CH2:1]([OH:4])[C:2]#[CH:3].[CH2:5]([SnH:9]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:10][CH2:11][CH2:12][CH3:13])[CH2:6][CH2:7][CH3:8]>C1(C)C=CC=CC=1>[CH2:14]([Sn:9]([CH2:5][CH2:6][CH2:7][CH3:8])([CH2:10][CH2:11][CH2:12][CH3:13])/[CH:3]=[CH:2]/[CH2:1][OH:4])[CH2:15][CH2:16][CH3:17]

参加物

4

反応物 2

HCID 5948TributylstannaneHCID 7859Propargyl alcohol

生成物 1

HCID 10043273(E)-3-(tributylstannyl)prop-2-en-1-ol

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

To a mixture of propargyl alcohol (2.24 g) and α,α'-azoisobutyronitrile (0.10 g) in anhydrous toluene (150 ml) is added tributyltin hydride (12.9 ml) and the mixture heated at reflux for about 2.5 hours, cooled and concentrated in vacuo. The crude product is purified by flash chromatography in 15% ether in hexane to give the desired product.

後処理

  1. temperaturethe mixture heated
  2. temperatureat reflux for about 2.5 hours
  3. temperaturecooled
  4. concentrationconcentrated in vacuo
  5. customThe crude product is purified by flash chromatography in 15% ether in hexane

出典と根拠

ORDレコード
ord-96f7297063ff4536a13820f86abb994a
出典データセット
uspto-grants-1993_06
特許番号
US05216015

反応ノート

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