関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | 4-Toluenesulfonyl chloride | HCID 7397 | — |
| 溶媒 | Pyridine | HCID 1049 | — |
| 生成物 | Benzenesulfonamide, 4-methyl-N-phenyl- | HCID 2456 | — |
反応手順
Dissolve aniline (930 mg, 10 mmol) in anhydrous pyridine (25 mL) and cool to 5° C. Add, by dropwise addition, p-toluenesulfonyl chloride (2.1 g, 11 mmol) and stir overnight. Partition between water and ethyl acetate and separate the organic phase. Wash the organic phase with cold 1N hydrochloric acid, saturated sodium hydrogen carbonate and brine. Dry (MgSO4) and evaporate the solvent in vacuo to give the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05217964 |
|---|
| 出典データセット | uspto-grants-1993_06 |
|---|
| ORD ID | ord-17afee4eb84643fa9f4983b8a056dfdb |
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| 出典メモ | uspto-grants-1993_06 |
|---|
