2-Iodo-6-methylpyrazine → HCID 19756178、化合物

反応式

[CH2:1]([O:8][C:9]([N:11]1[CH2:16][CH:15]2[CH2:17][CH2:18][CH:12]1[C:13](=O)[CH2:14]2)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.I[C:21]1[CH:26]=[N:25][CH:24]=[C:23]([CH3:27])[N:22]=1>>[CH3:27][C:23]1[N:22]=[C:21]([CH:13]2[CH:12]3[CH2:18][CH2:17][CH:15]([CH2:16][N:11]3[C:9]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[O:10])[CH2:14]2)[CH:26]=[N:25][CH:24]=1

参加物

反応物 2

HCID 157501322-Iodo-6-methylpyrazine

HCID 189664272-Azabicyclo[2.2.2]octane-2-carboxylic acid, 6-oxo-, phenylmethyl ester

生成物 1

HCID 19756178HCID 19756178、化合物

実験手順

The title compound (666 mg) was prepared from 2-benzyloxycarbonyl-2-azabicyclo[2.2.2]octan-6-one and 2-iodo-6-methylpyrazine as described in Example 3. The alcohol obtained was dehydrated using potassium hydride, iodomethane and carbon disulphide as described in Example 3.

出典と根拠

ORDレコード: ord-648f318f26714748b7cf1160002f61b3
出典データセット: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05219849

反応ノート

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