Methyl 4-(2-aminopropyl)benzoate → N-[2-(4-Carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(thiazol-4-yl)ethanamine

HRID 1587915ノート

反応式

HRID 1587915 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH2:14])[CH3:13])=[CH:7][CH:6]=1)([O:3][CH3:4])=[O:2].Br[CH2:16][C:17]([C:19]1[N:20]=[CH:21][S:22][CH:23]=1)=[O:18]>>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([NH:14][CH2:16][CH:17]([OH:18])[C:19]2[N:20]=[CH:21][S:22][CH:23]=2)[CH3:13])=[CH:7][CH:6]=1)([O:3][CH3:4])=[O:2]

参加物

3

反応物 2

HCID 15034329Methyl 4-(2-aminopropyl)benzoateHCID 199741722-Bromo-1-(thiazol-4-yl)ethanone

生成物 1

HCID 19380205N-[2-(4-Carbomethoxyphenyl)-1-methylethyl]-2-hydroxy-2-(thiazol-4-yl)ethanamine

実験手順

Prepared analogously to Example 3 by reaction of 2-(4-carbomethoxyphenyl)-1-methylethylamine with 4-bromoacetyl-thiazole, followed by reduction and purification of the base on a silica gel plate using ethyl acetate/methanol=8:2 as eluant.

後処理

  1. customfollowed by reduction and purification of the base on a silica gel plate

出典と根拠

ORDレコード
ord-7c830cd6ce4047ca9e04aec3eafa8720
出典データセット
uspto-grants-1993_06
特許番号
US05219852

反応ノート

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