Acetyl chloride → HCID 19896706、化合物

HRID 1588333ノート

反応式

HRID 1588333 の反応式
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12](=[O:19])[CH:13]([CH3:18])[CH2:14][C:15]([OH:17])=[O:16])=[CH:11][C:5]=2[O:4][CH2:3]1.[C:20](Cl)(=O)C>CO>[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[CH:9][C:10]([C:12](=[O:19])[CH:13]([CH3:18])[CH2:14][C:15]([O:17][CH3:20])=[O:16])=[CH:11][C:5]=2[O:4][CH2:3]1

参加物

4

反応物 2

HCID 6367Acetyl chlorideHCID 11065271HCID 11065271、化合物

生成物 1

HCID 19896706HCID 19896706、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

4-(3,4-Dihydro-3-oxo-1,4(2H)-benzoxazin-7-yl)-4-Oxo-3-methylbutyric acid (5 g) was suspended in methanol (50 ml) and acetyl chloride (0.5 ml) added. The mixture was heated on a steam bath until all of the solid dissolved. The solvent was evaporated at reduced pressure providing the ester as a white foam which was recrystallized from ethyl acetate-methanol to give the product as white crystals, yield 5 g, mp 95°-98° C.

後処理

  1. temperatureThe mixture was heated on a steam bath until all of the solid
  2. dissolutiondissolved
  3. customThe solvent was evaporated at reduced pressure

出典と根拠

ORDレコード
ord-0d9dfcf3a5f0431eba040eb878f71927
出典データセット
uspto-grants-1993_06
特許番号
US05221742

反応ノート

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