Potassium Hydroxide → N-(2-morpholinophenyl)cyanamide

HRID 1588683ノート

反応式

HRID 1588683 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[NH:13][C:14]([NH2:16])=S)[CH2:3][CH2:2]1.[OH-].[K+].O.O.O.C([O-])(=O)C.[Pb+2].C([O-])(=O)C>O>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[NH:13][C:14]#[N:16])[CH2:5][CH2:6]1

参加物

5

反応物 3

HCID 14797Potassium HydroxideHCID 22456Lead diacetate trihydrateHCID 27411931-(2-Morpholinophenyl)thiourea

生成物 1

HCID 15746517N-(2-morpholinophenyl)cyanamide

試薬・触媒・溶媒 1

HCID 962Water溶媒3 回

実験手順

1-(2-morpholinophenyl)thiourea (10.5 g) was suspended in boiling water (80 ml) and a solution of potassium hydroxide (25.2 g) in hot water (70 ml) was added. The mixture was heated to 90°0 C. and aliquot portions of a hot solution of lead acetate trihydrate (17.5 g) in water (80 ml) added and the mixture heated under reflux for 10 minutes and cooled to ambient temperature. The mixture was filtered and the filtrate acidified with acetic acid to pH 6. The solid which formed was separated by filtration, washed with water and recrystallised from ethylacetate to give N-(2-morpholinophenyl)cyanamide (m.p. 175°-176° C.).

後処理

  1. temperatureThe mixture was heated to 90°0 C
  2. temperaturethe mixture heated
  3. temperatureunder reflux for 10 minutes
  4. filtrationThe mixture was filtered
  5. customThe solid which formed
  6. customwas separated by filtration
  7. washwashed with water
  8. customrecrystallised from ethylacetate

出典と根拠

ORDレコード
ord-f74e98d3c42e4452ac65ed4a9be53fe7
出典データセット
uspto-grants-1993_06
特許番号
US05223498

反応ノート

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