Dimethylamine → 5-Chloro-2-morpholinophenylguanidine
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[C:6]([NH:8][C:9]#[N:10])[CH:7]=1.C[NH:18]C>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[C:6]([NH:8][C:9]([NH2:18])=[NH:10])[CH:7]=1参加物
4
実験手順
In a similar manner to that described in Example 272, N-(5-chloro-2-morpholinophenyl)cyanamide (2.3 g) in ethanol (10 ml) and a 33% ethanolic solution of dimethylamine (6 ml) were heated under reflux for 4 hours to give 1,1-dimethyl-2-(5-chloro-2-morpholinophenylguanidine (m.p. 135°-138° C.) which was recrystallised from hexane and then was converted into its monofumarate salt (m.p. 223°-225° C.) which was recrystallised from methanol.
後処理
- temperatureunder reflux for 4 hours
出典と根拠
- ORDレコード
- ord-f4ac72f7bee24272a68ed04e653cac00
- 出典データセット
- uspto-grants-1993_06
- 特許番号
- US05223498
反応ノート
読み込み中…