3-Cyclopropyl-3-(4-chlorophenyl)propan-1-ol → 3-Cyclopropyl-3-(4-chlorophenyl)propionaldehyde

HRID 1588877ノート

反応式

HRID 1588877 の反応式
[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[CH:12]1([CH:15]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[CH2:16][CH2:17][OH:18])[CH2:14][CH2:13]1>C(Cl)Cl.C(OCC)C>[CH:12]1([CH:15]([C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)[CH2:16][CH:17]=[O:18])[CH2:14][CH2:13]1

参加物

5

反応物 2

HCID 197548323-Cyclopropyl-3-(4-chlorophenyl)propan-1-olHCID 178418287HCID 178418287、化合物

生成物 1

HCID 197548433-Cyclopropyl-3-(4-chlorophenyl)propionaldehyde収率 24%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 6344Dichloromethane溶媒2 回

実験手順

A mixture of 6.5 grams (0.03 mole) of pyridinium chlorochromate in 25 ml of methylene chloride was stirred, and a solution of 2.1 grams (0.03 mole) of 3-cyclopropyl-3-(4-chlorophenyl)propan-1-ol in 5 ml of methylene chloride was quickly added. Upon completion of addition, the reaction mixture was stirred at ambient temperature for one hour. The reaction mixture was then diluted with 100 ml of diethyl ether, and this mixture was filtered through a pad of activated magnesium silicate. The filtrate was concentrated under reduced pressure, yielding 1.5 grams of 3-cyclopropyl-3-(4-chlorophenyl)propionaldehyde.

後処理

  1. additionUpon completion of addition
  2. stirringthe reaction mixture was stirred at ambient temperature for one hour
  3. filtrationthis mixture was filtered through a pad of activated magnesium silicate
  4. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-e7b8daec8f9d4998aad5ea326c1e59dc
出典データセット
uspto-grants-1993_06
特許番号
US05223536

反応ノート

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