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3-(Chloromethyl)pyridine hydrochloride → 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-3-(3-pyridinylmethyl)-2-imidazolidinone dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Chloromethyl)pyridine hydrochloride | HCID 23394 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 反応物 | GSK163090 (dihydrochloride) | HCID 49836021 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-(3-{2-[4-(2-Methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-3-(3-pyridinylmethyl)-2-imidazolidinone dihydrochloride | HCID 57478382 | — |
反応手順
The title compound was prepared according to the procedure described for Example 156 using 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (Example 85, 50 mg), DMF (1 mL), sodium hydride (60%, 14 mg) and 3-chloromethylpyridine hydrochloride (20 mg). Yield, 20 mg.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732600B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-79dc480f4f50484a9d1576f45a420a98 |
| 出典メモ | uspto-grants-2010_06 |