Benzylamine → N-(2-Methoxyphenyl)-2-[(phenylmethyl)amino]acetamide

HRID 1588975ノート

反応式

HRID 1588975 の反応式
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl[CH2:10][C:11]([NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[O:20][CH3:21])=[O:12]>C(O)C>[CH3:21][O:20][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[NH:13][C:11](=[O:12])[CH2:10][NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 7504BenzylamineHCID 416472-Chloro-N-(2-methoxyphenyl)acetamide

生成物 1

HCID 14998796N-(2-Methoxyphenyl)-2-[(phenylmethyl)amino]acetamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To ethanol (100 mL) add benzylamine (35 g, 0.33 mol) and 2-chloro-N-(2-methoxyphenyl)acetamide (22 g, 0.11 mol). Stir and heat the reaction at 50° C. Monitor the progress of the reaction by thin-layer chromatography. Upon completion of the reaction remove the precipiate that has formed by suction filtration and discard. Evaporate the filtrate and partition the residue between ethyl acetate and 2N NaOH(aq). Separate the organic layer and dry it over Na2SO4. Remove the drying agent by filtration and remove the solvent in vacuo. Chromatograph the residue on silica gel (400 g) using hexane/EtOAc (3/1) as eluent to obtain the title compound.

後処理

  1. temperatureheat
  2. customthe reaction at 50° C
  3. customMonitor the progress of the reaction by thin-layer chromatography
  4. customUpon completion of the reaction remove the precipiate that
  5. customhas formed by suction filtration and discard
  6. customEvaporate the filtrate
  7. custompartition the residue between ethyl acetate and 2N NaOH(aq)
  8. customSeparate the organic layer
  9. dry with materialdry it over Na2SO4
  10. customRemove the drying agent
  11. filtrationby filtration
  12. customremove the solvent in vacuo

出典と根拠

ORDレコード
ord-50518e9c9e464466bcbfbb1404c9a4af
出典データセット
uspto-grants-1993_06
特許番号
US05223623

反応ノート

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